Seroevidence for #H5N1 #Influenza Infections in Humans: Meta-Analysis
The prevalence of avian H5N1 influenza A infections in humans has not
been definitively determined. Cases of H5N1 infection
in humans confirmed by the World Health
Organization (WHO) are fewer than 600 in number, with an overall case
fatality rate
of >50%. We hypothesize that the stringent
criteria for confirmation of a human case of H5N1 by WHO does not
account for a
majority of infections, but rather, the select
few hospitalized cases that are more likely to be severe and result in
poor
clinical outcome. Meta-analysis shows that 1 to
2% of more than 12,500 study participants from 20 studies had
seroevidence
for prior H5N1 infection.
Reference
Science DOI: 10.1126/science.1218888
Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis
Taia T. Wang,
Michael K. Parides,
Peter Palese
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